Concise Synthesis of ( ± ) - Smenochromene D ( = Likonide B )
نویسندگان
چکیده
SYNLETT 2005, No. 4, pp 0700–070204.03.2005 Advanced online publication: 22.02.2005 DOI: 10.1055/s-2005-863713; Art ID: Y04404ST © Georg Thieme Verlag Stuttgart · New York Abstract: The total synthesis of smenochromene D, an unusual ansa-terpenoid is described. The synthesis features an unprecedented macrocyclization proceeding through a biomimetic electrocyclization. The enantiomeric relationship between smenochromene D and likonide B is established.
منابع مشابه
Hepatitis B Virus Infection in Patients with Blood Disorders: A Concise Review in Pediatric Study
Childhood Hepatitis B virus (HBV) infection causes both medical and public health challenges. Infants who acquire HBV parentally have up to 90% risk of developing chronic HBV infection. It is now estimated that approximately 10% of worldwide cancers are attributable to viral infection, with the vast majority (>85 %) occurring in the developing world. In this distribution, elevated rate and prev...
متن کاملStereocontrolled synthesis of 20,21-dihydro N-methylwelwitindolinone B isothiocyanate.
Described is a concise synthesis of the 20,21-dihydro analog of N-methylwelwitindolinone B isothiocyanate, wherein a cationic homoallyl to cyclopropylmethyl rearrangement is circumvented by hydrogenation of the offending double bond.
متن کاملSilenes in organic synthesis: a short synthesis of prelactone B.
A sequence involving dihydroxylation and acid induced fragmentation of silene generated silacyclohexenes represents the key step in a concise synthetic route to beta-hydroxy-delta-lactones.
متن کاملPharmacological properties of some 3-substituted indole derivatives, a concise overview
Indole is a nitrogen-containing heterocycle. It is a very important motif in agriculture and pharmacy. Many compounds containing indole moiety has been isolated form nature. It is also an important part in natural alkaloids. Tryptophan is an amino acid which posses indole. 3-Sustituted indoles are the main group of its derivatives. Because the wide-spread application of 3-substituted indolic co...
متن کاملConcise Total Synthesis of (+)-Gliocladins B and C.
The first total synthesis of (+)-gliocladin B is described. Our concise and enantioselective synthesis takes advantage of a new regioselective Friedel-Crafts-based strategy to provide an efficient multigram-scale access to the C3-(3'-indolyl)hexahydropyrroloindole substructure, a molecular foundation present in a significant subset of epipolythiodiketopiperazine natural alkaloids. Our first-gen...
متن کامل